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Staged Mycosis Fungoides treatment by National Cancer Institute

Stage I Mycosis Fungoides/Sézary Syndrome

1. Phototherapy (PUVA therapy) with or without biological therapy.
2. Total skin electron beam radiation therapy (TSEB radiation therapy).
3. Topical chemotherapy.
4. Local electron beam or x-ray therapy to reduce the size of the tumor or to relieve symptoms.
5. Interferon alfa (biological therapy) alone or in combination with topical therapy.
6. Retinoids.


Stage II Mycosis Fungoides/Sézary Syndrome

1. Phototherapy (PUVA therapy) with or without biological therapy.
2. Total skin electron beam radiation therapy (TSEB radiation therapy).
3. Topical chemotherapy.
4. Local electron beam or x-ray therapy.
5. Interferon alfa (biological therapy) alone or in combination with topical therapy.
6. Retinoids.

Stage III Mycosis Fungoides/Sézary Syndrome

1. Phototherapy (PUVA therapy) with or without biological therapy.
2. Total skin electron beam radiation therapy (TSEB radiation therapy).
3. Local electron beam or x-ray therapy.
4. Chemotherapy for mycosis fungoides and Sézary syndrome.
5. Interferon alfa (biological therapy) alone or in combination with topical therapy.
6. Biological therapy.
7. Systemic chemotherapy with or without therapy to the skin.
8. Extracorporeal photochemotherapy.
9. Topical chemotherapy.
10. Retinoids.

Stage IV Mycosis Fungoides/Sézary Syndrome

1. Phototherapy (PUVA therapy) with or without biological therapy.
2. Total skin electron beam radiation therapy (TSEB radiation therapy).
3. Local electron beam or x-ray therapy.
4. Chemotherapy for mycosis fungoides and Sézary syndrome.
5. Interferon alfa (biological therapy) alone or in combination with topical therapy.
6. Biological therapy.
7. Systemic chemotherapy with or without therapy to the skin.
8. Topical chemotherapy.
9. Extracorporeal photochemotherapy.
10. Monoclonal antibody therapy.
11. Retinoids.

Recurrent Mycosis Fungoides/Sézary Syndrome

Treatment depends on many factors, including the type of treatment the patient received before. Depending on the patient's condition, treatment may be one of the following:

1. Local electron beam or x-ray therapy.
2. Total skin electron beam radiation therapy (TSEB radiation therapy).
3. Phototherapy (PUVA therapy).
4. Topical chemotherapy.
5. Systemic chemotherapy.
6. Extracorporeal photochemotherapy.
7. Clinical trials of biological therapy.
8. Clinical trials of bone marrow transplantation.

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